I use Mac OS 10.10.3 and NBPython under NB 8.0.2.
Upon installation the plug-ins successfully detect the Python 2.7 framework. However I want to work exclusively in Python 3 (3.4 currently) and that did not auto-detect.
With what is delivered from Apple plus using the standard Python 3 installer you end up with the frameworks in two different places:
/Library/Frameworks/Python.framework/Versions/3.4/bin/python3
/System/Library/Frameworks/Python.framework/Versions/2.7/
The work around is to install the platform manually and it works fine.